Pancreatic cancer
| PAG Title | Pancreatic cancer |
| PAG ID | WAG001433 |
| Type | P |
| Source Link |  KEGG |
| Publication Reference | NA |
| PAG Description | Infiltrating ductal adenocarcinoma is the most common maligncy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA). Normal duct epithelium progresses to infiltrating cancer through a series of histologically defined precursors (PanINs). The overexpression of HER-2/neu and activating point mutations in the K-ras gene occur early, ictivation of the p16 gene at an intermediate stage, and the ictivation of p53, SMAD4, and BRCA2 occur relatively late. Activated K-ras engages multiple effector pathways. Although EGF receptors are conventiolly regarded as upstream activators of RAS proteins, they can also act as RAS sigl transducers via RAS-induced autocrine activation of the EGFR family ligands. Moreover, PDA shows extensive genomic instability and aneuploidy. Telomere attrition and mutations in p53 and BRCA2 are likely to contribute to these phenotypes. Ictivation of the SMAD4 tumour suppressor gene leads to loss of the inhibitory influence of the transforming growth factor-beta siglling pathway. |
| Species | Homo sapiens |
| nCoCo Score | 3,782 |
| Base PAG ID | WAG001433 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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